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Sejun Kim

Postdoctoral Scholar

2026 - Present
Postdoctoral Scholars
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57Publications
1.3KCitations
Publication Timeline
2006: 0 papers
2007: 0 papers
2008: 1 paper
2009: 0 papers
2010: 2 papers
2011: 4 papers
2012: 1 paper
2013: 1 paper
2014: 3 papers
2015: 2 papers
2016: 3 papers
2017: 1 paper
2018: 1 paper
2019: 2 papers
2020: 3 papers
2021: 10 papers
2022: 4 papers
2023: 10 papers
2024: 6 papers
2025: 2 papers
20062025

Science and Engineering

Publications

2025

2 papers

Atomistic Mechanism Underlying the Regulation of the GPA1 G Protein Signaling Pathway Mediated by the Gibberellin A1 Phytohormone Binding to the GCR1 Plant G-Protein-Coupled Receptor

Pedro M. Hernández, Carlos A. Arango, Soo-Kyung Kim, Andrés Jaramillo-Botero, William A. Goddard III

#1710·2025·Journal of Chemical Information and Modeling

Metabotropic GABAB Receptor Activation Induced by G Protein Coupling

Moon Young Yang, Soo-Kyung Kim, William A. Goddard III

#1674·2025·J. Am. Chem. Soc.·3

2024

6 papers

Agonist activation to open the Gα subunit of the GPCR–G protein precoupled complex defines functional agonist activation of TAS2R5

Moon Young Yang, Khuong Duy Mac, Hannah R. Strzelinski, Samantha A. Hoffman, Donghwa Kim, et al.

#1657·2024·Proc. Natl. Acad. Sci. U.S.A.·6

Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments.

S. Hao, Brian Guthrie, Soo-Kyung Kim, S. Balanda, J. Kubicek, et al.

#1653·2024·Commun. Chem.·18

Experimental Validation of the Neurotrophic Factor-α1 Binding Site on the Serotonin Receptor 1E (HTR1E) Responsible for β-Arrestin Activation and Subsequent Neuroprotection

Xuyu Yang, Joo-Youn Lee, Soo-Kyung Kim, Y. Peng Loh, William A. Goddard III

#1648·2024·ACS Omega·1

The G Protein-First Mechanism for Activation of the Class B Glucagon-like Peptide 1 Receptor Coupled to N-Terminal Domain-Mediated Conformational Progression

Bo Li, Moon Young Yang, Soo-Kyung Kim, William A. Goddard III

#1647·2024·J. Am. Chem. Soc.·3

Ligand-Dependent and G Protein-Dependent Properties for the Sweet Taste Heterodimer, TAS1R2/1R3

Soo-Kyung Kim, Brian Guthrie, William A. Goddard III

#1646·2024·J. Phys. Chem. B·1

Methotrexate Inhibits the Binding of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Receptor Binding Domain to the Host-Cell Angiotensin-Converting Enzyme-2 (ACE-2) Receptor

Soo-Kyung Kim, Sartanee Suebka, Adley Gin, Phuong-Diem Nguyen, Yisha Tang, et al.

#1608·2024·ACS Pharmacology & Translational Science·12

2023

10 papers

Fully activated structure of the sterol-bound Smoothened GPCR-Gi protein complex

Amy-Doan P. Vo, Soo-Kyung Kim, Moon Young Yang, Alison E. Ondrus, William A. Goddard III

#1603·2023·Proc. Natl. Acad. Sci. U.S.A.·7

Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like Receptor 1 Antagonists for the Treatment of Psoriasis

Bongki Ko, Yongsoo Jang, Seung-hwa Kwak, Hyun You, Jeong-hyun Kim, et al.

#1599·2023·Journal of Medicinal Chemistry·2

Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease

Sujin Kim, Da Gyeong Hyun, Yunkwon Nam, Soo Jung Shin, Dongjoon Im, et al.

#1600·2023·Biomedicine & Pharmacotherapy·10

Structure and Molecular Mechanism of Signaling for the Glucagon-like Peptide-1 Receptor Bound to Gs Protein and Exendin-P5 Biased Agonist

Bo Li, Krystyna Maruszko, Soo-Kyung Kim, Moon Young Yang, Amy-Doan P. Vo, et al.

#1589·2023·J. Am. Chem. Soc.·10

The dynamics of agonist-β₂-adrenergic receptor activation induced by binding of GDP-bound Gs protein

Amirhossein Mafi, Soo-Kyung Kim, William A. Goddard III

#1584·2023·Nature Chemistry·27

Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions

Arundhati Nag, Amirhossein Mafi, Samir Das, Mary Beth Yu, Belen Alvarez-Villalonga, et al.

#1576·2023·Commun. Chem.·2

Predicted structure and cell signaling of TAS2R14 reveal receptor hyper-flexibility for detecting diverse bitter tastes

Alina Tokmakova, Donghwa Kim, Brian Guthrie, Soo-Kyung Kim, William A. Goddard III, et al.

#1564·2023·iScience·25

Discovery and Binding Mechanism of Pyrazoloisoquinoline-Based Novel β-Arrestin Inverse Agonists of the Kappa-Opioid Receptor

Jae-Hoon Jung, In Hee Jang, Moon Young Yang, Sunhong Kim, Soo-Kyung Kim, et al.

#1562·2023·Journal of Medicinal Chemistry·1

Predicted Three-Dimensional Structure of the GCR1 Putative GPCR in Arabidopsis thaliana and Its Binding to Abscisic Acid and Gibberellin A1

Pedro M. Hernández, Carlos A. Arango, Soo-Kyung Kim, Andrés Jaramillo-Botero, William A. Goddard III

#1572·2023·Journal of Agricultural and Food Chemistry·6

Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery

Xudong Wang, Chris Neale, Soo-Kyung Kim, William A. Goddard III, Libin Ye

#1558·2023·Nature Communications·18

2022

4 papers

Characterization of the Solid Electrolyte Interphase at the Li Metal–Ionic Liquid Interface

Moon Young Yang, Sergey V. Zybin, Tridip Das, Boris V. Merinov, William A. Goddard III, et al.

#1553·2022·Advanced Energy Materials·38

G protein coupling and activation of the metabotropic GABA₈ heterodimer

Moon Young Yang, Soo-Kyung Kim, William A. Goddard III

#1526·2022·Nature Communications·22

The mechanism for ligand activation of the GPCR–G protein complex

Amirhossein Mafi, Soo-Kyung Kim, William A. Goddard III

#1518·2022·Proc. Natl. Acad. Sci. U.S.A.·92

Complete inhibition of a polyol nucleation by a micromolar biopolymer additive

Xin Wen, Sen Wang, Robert Ramji, Luke O. Butler, Yelena Bagdagulyan, et al.

#1532·2022·Cell Rep. Phys. Sci.·3

2021

10 papers

Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling

Vinay Kumar Sharma, Xuyu Yang, Soo-Kyung Kim, Amirhossein Mafi, Daniel Saiz-Sanchez, et al.

#1503·2021·Cellular and Molecular Life Sciences·29

Synergic Effects in the Activation of the Sweet Receptor GPCR Heterodimer for Various Sweeteners Predicted Using Molecular Metadynamics Simulations

Jaewan Jang, Soo-Kyung Kim, Brian Guthrie, William A. Goddard III

#1492·2021·Journal of Agricultural and Food Chemistry·22

Predicted Structure of Fully Activated Tas1R3/1R3′ Homodimer Bound to G Protein and Natural Sugars: Structural Insights into G Protein Activation by a Class C Sweet Taste Homodimer with Natural Sugars

Amirhossein Mafi, Soo-Kyung Kim, Keng C. Chou, Brian Guthrie, William A. Goddard III

#1491·2021·J. Am. Chem. Soc.·17

Structures and Agonist Binding Sites of Bitter Taste Receptor TAS2R5 Complexed with Gi Protein and Validated against Experiment

Moon Young Yang, Soo-Kyung Kim, Donghwa Kim, Stephen B. Liggett, William A. Goddard III

#1489·2021·J. Phys. Chem. Lett.·19

The G protein-first activation mechanism of opioid receptors by Gi protein and agonists

Amirhossein Mafi, Soo-Kyung Kim, William A. Goddard III

#1480·2021·QRB Discovery·18

Transport properties of imidazolium based ionic liquid electrolytes from molecular dynamics simulations

Moon Young Yang, Boris V. Merinov, Sergey V. Zybin, William A. Goddard III, Eun Kyung Mok, et al.

#1499·2021·Electrochemical Science Advances·10

Autobifunctional Mechanism of Jagged Pt Nanowires for Hydrogen Evolution Kinetics via End-to-End Simulation

Geun Ho Gu, Juhyung Lim, Chengzhang Wan, Tao Cheng, Heting Pu, et al.

#1421·2021·J. Am. Chem. Soc.·44

Predicted structure of fully activated human bitter taste receptor TAS2R4 complexed with G protein and agonists

Moon Young Yang, Amirhossein Mafi, Soo-Kyung Kim, William A. Goddard III, Brian Guthrie

#1465·2021·QRB Discovery·17

Hedgehog proteins create a dynamic cholesterol interface

Amirhossein Mafi, Rahul Purohit, Erika Vielmas, Alexa R. Lauinger, Brandon Lam, et al.

#1415·2021·PLoS ONE·12

Structural Variation and Odorant Binding for Olfactory Receptors Selected from the Six Major Subclasses of the OR Phylogenetic Tree

M. Malinska, Soo-Kyung Kim, William A. Goddard III, M. Ashok

#1435·2021·In: Computational Materials, Chemistry, and Biochemistry: From Bold Initiatives to the Last Mile ; Springer Series in Materials Science, No. 284; (S. Shankar, R. Muller, T. Dunning and G.H. Chen), Springer, Cham, 2021, pp.855–925.·2